Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

Min Ji Kim; You Ri Park; GiBong Jang; Yong Han; Isao Ishii; Se Young Jang; Kwon Moo Park

doi:10.1177/15230864251377735

September 17, 2025Antioxidants and Redox Signaling

Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

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Key Points

Cystathionine γ-lyase protects against liver disease triggered by a high-fat diet, supporting its therapeutic role.
Key findings show that CSE involvement can reduce oxidative stress associated with MASLD progression.
The study employed a mouse model to investigate MASLD, providing insights into its biochemical mechanisms.
This research underscores the need for further exploration of cysteine-based therapies for metabolic liver diseases.

Implication

Observational analysis revealed that cystathionine γ-lyase counters oxidative stress in MASLD, indicating therapeutic potential.

Abstract

Aim: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver disease, yet its pathogenesis remains incompletely understood. Oxidative stress is thought to play a key role in MASLD progression. This study aimed to investigate the role of cystathionine γ-lyase (CSE), an enzyme essential for cysteine and glutathione (GSH) biosynthesis, in MASLD development.

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68d462ca31b076d99fa6223b https://doi.org/10.1177/15230864251377735

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Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

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