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September 18, 2025Journal of Sports Sciences

Combined effects of physical activity and diet on chronic inflammation of overweight/obese children and adolescents: A systematic review and meta-analysis

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Authors

CZConstantine ZalagkitisΑPΑnastassios PhilippouEKEleftherios Karatzanos

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Overview

Systematic review demonstrates positive effects of diet and physical activity on chronic inflammation in youth, suggesting better health outcomes.

Key Points

  • Combined physical activity and diet interventions likely reduce C-reactive protein and IL-6 in youth with obesity.
  • Meta-analysis showed a significant decrease in IL-1β and IL-8, while no changes in IL-10 were found.
  • Evidence suggests that lifestyle changes can positively impact chronic inflammation indices in overweight and obese adolescents.
  • Fifty eligible publications were analyzed, following rigorous systematic review protocols for reliable conclusions.

Cite This Study

Zalagkitis et al. (2025) studied this question.

synapsesocial.com/papers/68d462ca31b076d99fa622f8https://doi.org/10.1080/02640414.2025.2561349
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Does Physical Activity-Based Intervention Improve Systemic Proinflammatory Cytokine Levels in Overweight or Obese Children and Adolescents? Insights from a Meta-Analysis of Randomized Control Trials2019 · 46 citations
  2. 2Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial2024 · 6 citations
  3. 3Effects of different exercise modalities on inflammatory markers in the obese and overweight populations: unraveling the mystery of exercise and inflammation2024 · 7 citations
  4. 4Effectiveness of physical activity in obese children and adolescents and serum interleukin-10 levels: A protocol for systematic review2024
  5. 5Effects of Vitamin D3 Supplementation on Inflammatory Markers in Overweight and Obese Children and Adolescents: A Systematic Review2025 · 1 citations