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September 18, 2025International Journal of Molecular SciencesOpen Access

STINGing Cancer: Development, Clinical Application, and Targeted Delivery of STING Agonists

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Authors

YNYannick Gabriel NerdingerABAmanda Katharina BinderFBFranziska Bremm

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Overview

Review highlights effects of STING agonists on immune cells in cancer, suggesting unique delivery approaches.

Key Points

  • STING agonists may enhance immune response in tumors, but clinical success is still limited.
  • Promising results from preclinical studies suggest STING agonists can affect immune cell function in the tumor microenvironment.
  • Nanotechnological methods are being explored to improve delivery and effectiveness of STING agonists.
  • Multiple STING agonists have been evaluated in clinical trials, focusing on their interaction with macrophages.

Cite This Study

Nerdinger et al. (2025) studied this question.

synapsesocial.com/papers/68d462ca31b076d99fa62334https://doi.org/10.3390/ijms26189008
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