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September 18, 2025Frontiers in EndocrinologyOpen Access

Epigenetic modification of hypothalamic neuropeptides and metabolic hormone receptors in metabolic health

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Authors

BOBusayo OladunSMSmita MallMKMin‐Hyun Kim

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Overview

Review uncovers how environmental factors impact epigenetic regulation of neuropeptides and hormone receptors, indicating pathways to obesity treatment.

Key Points

  • Epigenetic changes in hypothalamic neuropeptides significantly affect metabolic health over generations.
  • Key modifications include DNA methylation and histone changes that disrupt energy homeostasis.
  • Environmental factors like diet and stress play critical roles in shaping these epigenetic alterations.
  • Understanding these mechanisms could lead to new therapeutic strategies for obesity and metabolic disorders.

Cite This Study

Oladun et al. (2025) studied this question.

synapsesocial.com/papers/68d462db31b076d99fa627f4https://doi.org/10.3389/fendo.2025.1645474
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