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September 18, 2025Frontiers in MedicineOpen Access

Relative efficacy of minoxidil in combination with other treatments for androgenic alopecia: a network meta-analysis based on randomized controlled trials

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Authors

YXYang XiaFuling Center Hospital of ChongqingHCHong ChenBeijing Hospital of Traditional Chinese MedicineYCYongsong ChenShantou University

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Implication

Network meta-analysis reveals minoxidil's effectiveness combined with other treatments in androgenetic alopecia, suggesting optimized management strategies.

Key Points

  • The combination of platelet-rich plasma with minoxidil increased hair density by 35.12 hairs/cm², showcasing the highest efficacy among treatments.
  • In male subgroups, finasteride paired with minoxidil had a SUCRA value of 80.18%, marking it as the most effective combination.
  • A Bayesian network meta-analysis was performed on 20 study groups, evaluating multiple treatment combinations using SUCRA values.
  • Establishing a hierarchy among minoxidil therapies provides evidence-based guidelines for dermatologists treating androgenetic alopecia.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/68d462db31b076d99fa62897https://doi.org/10.3389/fmed.2025.1638496
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: A prospective, randomized, controlled, assessor blinded, 3‐arm, pilot trial2023 · 22 citations
  2. 2Relative Effects of Minoxidil 5%, Platelet-Rich Plasma, and Microneedling in Pattern Hair Loss: A Systematic Review and Network Meta-Analysis2023 · 10 citations
  3. 3Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population2022 · 15 citations
  4. 4Efficacy comparison of monotherapies and combination therapies for androgenetic alopecia: A Bayesian network<scp>meta‐analysis</scp>2021 · 5 citations
  5. 5Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical solution for the treatment of Chinese male Androgenetic alopecia2017 · 63 citations