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September 18, 2025Frontiers in Public HealthOpen Access

Hemoglobin-to-red blood cell distribution width ratio in the relationship between occupational aluminum exposure and cognitive function impairment: a mediation analysis

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Authors

RWRuonan WangZWZ. WangWHWilliam T. Hu

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Overview

Mediation analysis reveals aluminum exposure negatively affects cognitive function in workers, implicating HRR.

Key Points

  • Cognitive function impairment was significantly associated with aluminum exposure in workers.
  • Plasma aluminum concentration was negatively correlated with both HRR and cognitive function scores.
  • Each unit increase in plasma aluminum led to a reduction in HRR by 0.17 and MoCA score by 0.9.
  • HRR mediated approximately 9.89% of the effect of aluminum exposure on cognitive scores.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d463db31b076d99fa62e53https://doi.org/10.3389/fpubh.2025.1639229
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain functional connectivity network alterations in occupational aluminum exposure among workers with mild cognitive impairment2026
  2. 2OCCUPATIONAL EXPOSURE TO ALUMINUM AND COGNITIVE PERFORMANCE2024
  3. 3Assessment of anxiety risk association with PAHs and aluminum co-exposure in an aluminum production facility2026
  4. 4Effects of multiple metals exposure on abnormal liver function: The mediating role of low-density lipoprotein cholesterol2024 · 12 citations
  5. 5Association of hemoglobin-to-red blood cell distribution width ratio and cognition: A cross-sectional study2024 · 1 citations