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This is a Experimental Study study.

September 18, 2025Frontiers in PhysiologyOpen Access

Human red blood cell ATP content and export under hypoxic and/or isocapnic storage conditions

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Experimental assessment of ATP dynamics in red blood cells reveals hypoxia impacts transfusion outcomes.

Red blood cells stored under hypoxia showed increased ATP content during mid-storage, enhancing oxygen delivery.
ATP export from red blood cells declined over storage, with significant boosts observed only at one-week intervals under CO2 preservation.
Hypoxic storage led to a differential modulation of ATP and biphosphoglycerate levels, but did not significantly affect ATP export.
Future research can explore how the storage effects on ATP and BPG inform personalized transfusion strategies.

Chen et al. (2025) studied this question.

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