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September 18, 2025PharmaceuticsOpen Access

Optimizing Dose Conversion from IR-Tac to LCP-Tac Formulations in Renal Transplant Recipients: A Population Pharmacokinetic Modeling Study

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Authors

ZAZeyar Mohammed AliBFBeatriz Fernández-AlarcónPFPere Fontova

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Overview

Population pharmacokinetic modeling reveals CYP3A5 genotype affects tacrolimus conversion ratios in renal transplant patients, suggesting genotype-informed dosing strategies.

Key Points

  • CYP3A5 polymorphism significantly influences tacrolimus clearance, necessitating tailored dosing strategies.
  • Optimal conversion ratios determined were 1:0.6 for CYP3A5 expressers and 1:0.7 for non-expressers.
  • Population pharmacokinetic modeling established a two-compartment model for tacrolimus with improved clearance predictions.
  • Genotype-specific dosing recommendations aim to enhance individualized care in renal transplantation.

Cite This Study

Ali et al. (2025) studied this question.

synapsesocial.com/papers/68d463e231b076d99fa62ffchttps://doi.org/10.3390/pharmaceutics17091185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimizing Dose Conversion From IR-Tac to LCP-Tac Formulations in Renal Transplant Recipients: A Population Pharmacokinetic Modeling Study2025
  2. 2Tacrolimus Conversion in CYP3A5*1 Expressers: From Immediate-Release to LCP Formulation2025
  3. 3Guiding the starting dose of the once-daily formulation of tacrolimus in “de novo” adult renal transplant patients: a population approach2024 · 3 citations
  4. 4Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients2026
  5. 5Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase2025 · 1 citations