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September 23, 2025European Journal of Clinical PharmacologyOpen Access

Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase

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Authors

SZShouning ZhouFirst Affiliated Hospital of Guangzhou Medical UniversityQLQiaoyan LianFirst Affiliated Hospital of Guangzhou Medical UniversityHLHuilong LuoGuangzhou Medical University

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Implication

Population pharmacokinetic modeling improves tacrolimus dosing regimens for lung transplant recipients, suggesting personalized approaches.

Key Points

  • Tacrolimus dosing can be optimized through population pharmacokinetic modeling in lung transplant recipients.
  • The study collected 988 tacrolimus trough concentrations from 142 patients, providing comprehensive data for analysis.
  • A one-compartment model was used to describe tacrolimus pharmacokinetics, particularly its clearance rates across different CYP3A5 genotypes.
  • Tailored dosing regimens based on genetic and clinical factors can enhance therapeutic outcomes for lung transplant recipients.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d46fdc31b076d99fa6a766https://doi.org/10.1007/s00228-025-03920-9
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Importance of hematocrit for a tacrolimus target concentration strategy2013 · 142 citations
  2. 2Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and <i>CYP3A5</i> genotype‐guided doses in renal transplantation patients2019 · 30 citations
  3. 3Pharmacogenetics Based Dose Prediction Model for Initial Tacrolimus Dosing in Renal Transplant Recipients2021 · 18 citations