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Multi-Omics in Predicting Lamotrigine Neurotoxicity: Current Opportunities (Review)

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Review discusses how pharmacogenomics influences lamotrigine neurotoxicity in epilepsy treatment, highlighting the need for personalized therapy.

Lamotrigine neurotoxicity can be influenced by genetic factors, leading to serious adverse effects and complications.
Toxic lamotrigine metabolites persist in circulation, affecting neurotransmission and synaptic health in patients.
Monitoring toxic metabolites and conducting pharmacogenomic tests may optimize lamotrigine therapy and reduce risks.
Assessing drug distribution is essential for understanding lamotrigine's safety and efficacy in individual patients.

Shnayder et al. (2025) studied this question.

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View Full Paper

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Authors

Review discusses how pharmacogenomics influences lamotrigine neurotoxicity in epilepsy treatment, highlighting the need for personalized therapy.

Lamotrigine neurotoxicity can be influenced by genetic factors, leading to serious adverse effects and complications.
Toxic lamotrigine metabolites persist in circulation, affecting neurotransmission and synaptic health in patients.
Monitoring toxic metabolites and conducting pharmacogenomic tests may optimize lamotrigine therapy and reduce risks.
Assessing drug distribution is essential for understanding lamotrigine's safety and efficacy in individual patients.

Shnayder et al. (2025) studied this question.

View Full Paper

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Bookmark