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September 18, 2025Frontiers in Behavioral NeuroscienceOpen Access

Sub-chronic stress exerts partially distinct behavioral and epigenetic effects in male and female mice

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Authors

MDMatthew J. DomanicoVillanova UniversitySSS. S. StevensUniversity of CologneIWIris WainstonVillanova University

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Overview

Experimental analysis reveals sex differences in stress-induced behavioral outcomes and epigenetic changes in mice, indicating unique vulnerabilities.

Key Points

  • Stress exposure influenced behavior and DNA methylation differently in male and female mice.
  • Significant behavioral consequences were observed following sub-chronic stress in both sexes, though effects varied.
  • Statistical analyses indicated sex-specific changes in DNA methylation of certain genes linked to stress in the nucleus accumbens.
  • Results suggest that understanding sex differences can enhance strategies for treating stress-related disorders.

Cite This Study

Domanico et al. (2025) studied this question.

synapsesocial.com/papers/68d463e931b076d99fa634f2https://doi.org/10.3389/fnbeh.2025.1649660
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