Case series demonstrates significant recovery from myopathy symptoms in young women with osteomalacia, implying the need for early treatment with vitamin D and calcium.
Osteomalacia is a metabolic bone disorder characterized by progressive softening of bones due to Vitamin D deficiency. Osteomalacic myopathy presents with proximal muscle weakness, bone pain, and muscle spasms. Two cases are described in this case series: Case 1: A 29-year-old female with bilateral thigh pain, difficulty getting up from supine posture, and walking. She had power -4+/5 in bilateral hips and Looser’s zones on pelvic X-ray. Case 2: A 17-year-old female with lateral abdominal pain radiating to the thigh, tightness in limbs, and difficulty getting up from supine posture. She had mild proximal weakness and Looser’s zones on pelvic X-ray. Both patients were treated with calcium and Vitamin D supplementation, showing significant improvement on follow-up. Osteomalacic syndrome is reversible with specific treatment, highlighting the importance of early diagnosis and intervention.
No takes yet. Share an insight, caveat, or question.
Anugu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: