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September 18, 2025Open Access

Compartment-specific Fat Distribution Profiles have Distinct Relationships with Cardiovascular Ageing and Future Cardiovascular Events

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Authors

CMCynthia Maldonado-GarciaASAhmed SalihSNStefan Neubauer

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Overview

Observational analysis shows that different fat types impact cardiovascular ageing, suggesting new risk assessment methods.

Key Points

  • Distinct fat distribution profiles significantly impact cardiovascular ageing and future cardiovascular events, revealing new risk dynamics.
  • Mediation analysis indicates visceral and pericardial fat are primary contributors to CVD risk, while subcutaneous fat plays a minor role.
  • Using machine learning on cardiac MRI data, the study identified high and low-risk fat distribution clusters linked to cardiac ageing.
  • Findings suggest advanced adiposity profiling can improve CVD risk prediction beyond traditional measures.

Cite This Study

Maldonado-Garcia et al. (2025) studied this question.

synapsesocial.com/papers/68d463f131b076d99fa638e4https://doi.org/10.1101/2025.09.16.25335879
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distinct relationships of compartment-specific fat distribution profiles with cardiovascular ageing and future cardiovascular events2026
  2. 2Body fat and human cardiovascular ageing2024
  3. 3Sex-specific body fat distribution predicts cardiovascular ageing2025 · 40 citations
  4. 4Abstract 49: Validation of Imaging-Derived Body Composition Subphenotypes Reflects Distinct Fat Distribution Patterns Associated with Different Degrees of Cardiovascular Disease Risk2026
  5. 5Age-related changes in adiposity and cardiometabolic disease risk: a longitudinal and prospective study in the UK Biobank2026