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September 19, 2025Science

Stereo-reversed E2 unlocks Z -selective C–H functionalization

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This approach enables Z-selective functionalization of alkenes through bis-sulfonium intermediates, implying new pathways for organic synthesis.

Z-selective elimination from bis-sulfonium intermediates provides efficient access to Z-alkenes.
Paired electrolysis selectively generates bis-sulfonium intermediates for rapid transformation.
This method challenges traditional E2 stereoselectivity using stabilizing interactions.
The resulting Z-alkenyl sulfonium allows robust cross-coupling from inexpensive feedstocks.

Verardi et al. (2025) studied this question.

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September 19, 2025Science

View Full Paper

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Authors

This approach enables Z-selective functionalization of alkenes through bis-sulfonium intermediates, implying new pathways for organic synthesis.

Z-selective elimination from bis-sulfonium intermediates provides efficient access to Z-alkenes.
Paired electrolysis selectively generates bis-sulfonium intermediates for rapid transformation.
This method challenges traditional E2 stereoselectivity using stabilizing interactions.
The resulting Z-alkenyl sulfonium allows robust cross-coupling from inexpensive feedstocks.

Verardi et al. (2025) studied this question.

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