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September 19, 2025

Anticancer potential of Dendrocnide meyeniana: phytochemical profiling, ADMET analysis, molecular docking, and in silico cytotoxicity evaluation

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Authors

EPEdlyn E. PootenKCKhristina Judan CruzEAEvaristo A. Abella

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Overview

Research demonstrates phytochemical profiling and ADMET evaluation in dendrocnide meyeniana, suggesting significant anticancer activity.

Key Points

  • Dendrocnide meyeniana exhibits strong anticancer potential, making it a promising candidate for drug development.
  • Among 78 identified phytochemicals, eight show favorable oral bioavailability, indicating good drug-likeness characteristics.
  • Molecular docking simulations reveal cryptotanshinone as a lead compound with better docking scores than traditional chemotherapeutics.
  • In silico cytotoxicity assessments highlight potential inhibitors for brain glioma and lymphoblastic leukemia cell lines from this plant.

Cite This Study

Pooten et al. (2025) studied this question.

synapsesocial.com/papers/68d464ea31b076d99fa641c0https://doi.org/10.21203/rs.3.rs-7568490/v1
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