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September 19, 2025Cancer Epidemiology Biomarkers & Prevention

Abstract C012: Atypical chemokine receptor 1 (ACKR1/DARC) is a biomarker of tumor immune response and prognosis in lung adenocarcinoma patients of African and European ancestry

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Authors

BJBenjamin T. JacksonNJNikita JinnaLELoretta Erhunmwunsee

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Overview

Analysis reveals ACKR1 impacts immune response and prognosis in lung adenocarcinoma patients, indicating racial disparities.

Key Points

  • Low ackr1 expression correlates with poorer overall survival in lung adenocarcinoma patients, suggesting a critical biomarker.
  • The study found that ackr1 gene expression is downregulated in LUAD tumors compared to normal tissue, highlighting its importance.
  • ACKR1 expression positively influences immune cells such as CD8+ T cells, and negatively correlates with suppressor cells in tumors.
  • Exploration of ackr1's role in lung adenocarcinoma may inform immunotherapeutic strategies tailored for diverse populations.

Cite This Study

Jackson et al. (2025) studied this question.

synapsesocial.com/papers/68d464f131b076d99fa643bdhttps://doi.org/10.1158/1538-7755.disp25-c012
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