Abstract This single-arm pilot study assessed changes in weight and body mass index (BMI) among Black breast cancer survivors with obesity and elevated stress in response to a stress-management enhanced, cancer relevant behavioral weight loss intervention (BWLI). Black women have a higher prevalence of obesity compared to White women (54. 8% vs. 38. 0%) 1. Current evidence-based BWLIs typically result in less weight loss among Black women which is associated with worse cancer survivorship. To date, there is a paucity of evidence-based BLWIs specifically tested among breast cancer survivors. As such, our team developed and pilot tested ‘Survivors RESET’, a structured lifestyle change program, adapted from the Centers for Disease Control-recognized Diabetes Prevention Program (DPP) Intensive Lifestyle Intervention. Eligible participants were cisgender women aged 18 or older, with BMI ≥ 30 kg/m2, a history of stage 0–3 breast cancer treated with curative intent, who completed treatments ≥ 21 days prior to enrollment (ongoing hormonal or Abemaciclib therapy was allowed), and elevated stress levels (Perceived Stress Scale Score ≥13). The DPP core curriculum was adapted to include stress management strategies and was tailored to be cancer relevant resulting in ‘Survivors RESET. ’ Participants completed 16 core sessions (out of the full 26-session curriculum). Weekly group-based 60-minute sessions were held via Zoom and led by a trained interventionist. Measures included a demographics survey and baseline height and weight assessed following a standardized protocol using a SECA 2-in-1 scale and stadiometer. Descriptive statistics were calculated and paired-samples Student's t-tests assessed within-group changes from baseline to 4 months. Twenty women enrolled, with a mean age of 57. 9±7. 7 years. Most participants were African American (n=17, 85%), 10% identified as Caribbean Black (n=2) ; racial/ethnic data were missing for one participant (5%). Most participants were born in the US (n=18, 90%), 70% (n=14) held a college degree or higher, 60% (n=12) reported an annual household income of ≥60, 000, and 70% (n=14) were employed. Results demonstrated statistically significant reductions in weight and BMI from baseline to 4 months. Mean weight decreased from 97. 8±17. 2 kg to 95. 5±17. 2 kg (p=0. 006), with a mean change of −2. 4 ± 3. 4 kg (−2. 4% of baseline). 75% of all participants lost weight. Among those who lost weight, mean weight loss was -3. 7±2. 7 kg (-6. 0% of baseline). Additionally, 53% of participants lost 3% of their baseline weight, indicating clinical significance. Mean BMI decreased from 37. 1±6. 4 kg/m2 to 36. 2±6. 5 kg/m2 (p=0. 006), with a mean change of −0. 9±1. 2 kg/m2. In this pilot study, significant decreases in weight and BMI were observed. Weight loss achieved in this 16-session pilot is comparable to weight loss achieved in many DPP adaptations that deliver a full 26-session curriculum over 1 year. These positive results for Survivors RESET suggest the intervention’s potential efficacy and underscore the need for a full scale, randomized controlled trial. Citation Format: Ana Paula S. Rodrigues, Ashley J. Cooper, Adana A M. Llanos, Khaliah F. Fleming, Sierra E. Pittman, Alissa Pena, Jazmin C. Henderson, Melissa A. Mallory, Steven K. Sutton, Heather S L. Jim, Marilyn Stern, Tiffany L. Carson. Exploring weight change among Black breast cancer survivors: A pilot study of ‘Survivors RESET’ abstract. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34 (9 Suppl): Abstract nr A023.
Rodrigues et al. (Thu,) studied this question.