Ophthalmological complications of antitumor therapy in patients with oncological diseases of various localizations

The current level of care for patients with cancer allows them to achieve remission or recovery in cases previously considered incurable. At the same time, the experience of possible side effects affecting the quality of life of patients is accumulating. In recent years, complications from the organ of vision have been described in the literature, affecting both the anterior segment of the eye, as well as the retina and optic nerve. The aim of the work is to analyze the features of the side effects of antitumor therapy of oncological diseases of various localization on the part of the organ of vision using clinical examples. Two cases of chemotherapy complications have been described: in breast cancer using tamoxifen, in diffuse B-cell lymphoma with bone marrow damage during vincristine therapy. The side effects of tamoxifen were characterized by a decrease in visual acuity in combination with crystalline deposits on the retina by the type of star shape, edema of the optic disc. The use of steroid therapy had a positive effect, visual acuity increased. The use of vincristine in the second clinical example led to damage to the optic nerve by the type of papillitis. The therapy did not lead to an increase in vision. The complications associated with vincristine therapy are dosedependent, timely withdrawal of the drug could preserve visual functions. Conclusion: the most toxic antitumor drugs for the organ of vision are alkylating agents, antimetabolites, mitosis inhibitors, hormonal agents, monoclonal antibodies, protein kinase inhibitors. The interaction between oncologists and ophthalmologists can maintain a high quality of life for patients with cancer.