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September 19, 2025Russian Journal of ImmunologyOpen Access

Estriol effect on proliferative activity of regulatory thymocyte subpopulations

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Authors

ИНИ. В. НекрасоваScientific Research Institute of Polymer Material (Russia)ОЛО. А. ЛогиноваRussian Academy of SciencesEOEkaterina G. OrlovaUral Branch of the Russian Academy of Sciences

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Implication

In vitro assessment shows estriol alters thymocyte populations, suggesting implications for immune tolerance during pregnancy.

Key Points

  • Estriol inhibits regulatory T cell formation while enhancing iNKT cell differentiation in thymocytes.
  • Flow cytometry revealed that estriol impacted the proliferation of Th17 cells, downregulating their response.
  • Thymocyte cultures with estriol demonstrated changes in immune cell composition linked to pregnancy.
  • These findings may help understand mechanisms behind steroid-induced thymus atrophy during pregnancy.

Cite This Study

Некрасова et al. (2025) studied this question.

synapsesocial.com/papers/68d464ff31b076d99fa6497bhttps://doi.org/10.46235/1028-7221-17166-eeo
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulatory T cell-mediated suppression: potential role of ICER2006 · 34 citations
  2. 2Pregnancy‐induced thymic involution is associated with suppression of chemokines essential for T‐lymphoid progenitor homing2016 · 56 citations
  3. 3Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.1994 · 681 citations
  4. 4REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy2010 · 1,110 citations
  5. 5The Biology of NKT Cells2006 · 2,153 citations