Radical addition induces dearomative spirocyclization and 1,4-alkyloximation of unactivated arenes, revealing synthetic pathways.
Nitrogenated spirocycles, as integral structural cores of numerous bioactive molecules, are valuable yet synthetically challenging three-dimensional scaffolds. Herein, we report a radical addition-induced dearomative spirocyclization/1,4-alkyloximation of unactivated arenes. The multicomponent protocol concurrently breaks the stable aromatic system and introduces multiple functional groups to synthesize highly decorated nitrogenated spirocycles via a radical cascade process.
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Shi et al. (2025) studied this question.
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