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Observational analysis revealed a 4-fold increase in de-escalation to narrow-spectrum antibiotics, suggesting the microbiology comment improves antibiotic prescribing practices.
Narrow-spectrum antibiotic prescribing (ampicillin IV or penicillin IV) was compared before and after implementing an interpretive microbiology comment for uncomplicated Streptococcus pneumoniae bloodstream infections. The postintervention group was associated with 4-fold increased odds of de-escalation to narrow-spectrum antibiotics (adjusted odds ratio, 4.66; 95% confidence interval, 1.97–11.00).
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Akon et al. (2025) studied this question.
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