Glandular cardiac myxomas: Pathological features and histogenesis

Cardiac myxomas (CMs) constitute one of the most common benign tumors of the heart, with a characteristic histomorphology of “lepidic cells” in an eosinophilic myxoid material, warranting immediate recognition. However, several, though uncommon, alterations in the classic pathological features hinder straightforward diagnosis. This is a report of one such intriguing entity, in which the myxoma shows the presence of glandular components, with a brief overview of the histogenesis, immunohistochemical characteristics, and differential diagnosis of glandular CMs.