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September 18, 2025eLifeOpen Access

Exploring the origins of a signaling pathway

Balaji Santhanam

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Key Points

Wnt proteins are part of a larger superfamily, indicating their evolutionary significance and widespread function.
There are 19 unique Wnt proteins identified in humans, linking to signaling pathways critical for cellular processes.
The signaling pathway associated with Wnt proteins shows relationships with similar proteins found in archaea and bacteria.
Understanding this pathway's origins may enhance insights into cellular communication across diverse organisms.

Implication

This analysis reveals insights into the signaling pathway by comparing Wnt proteins in humans, archaea, and bacteria.

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Cite This Study

Balaji Santhanam (2025) studied this question.

synapsesocial.com/papers/68d466a831b076d99fa64ee7 https://doi.org/10.7554/elife.108735

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