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September 19, 2025CellsOpen Access

Spike Timing-Dependent Plasticity at Layer 2/3 Horizontal Connections Between Neighboring Columns During Synapse Formation Before the Critical Period in the Developing Barrel Cortex

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Authors

CIChiaki ItamiFKFumitaka Kimura

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Overview

Research shows all-LTP STDP occurs at layer 2/3 connections in developing barrel cortex, indicating PKA involvement in synaptic plasticity.

Key Points

  • All-LTP STDP is evident at L2/3 connections during axon extension, crucial before critical period.
  • The presence of PKA signaling is vital for LTP-STDP induction, as indicated by effects of PKI 6-22.
  • Different mechanisms govern pre-post and post-pre timing induced LTP-STDP, showing complexity in synaptic development.
  • The findings highlight the role of L2/3-L2/3 connections in plasticity and the formation of neural circuits in the barrel cortex.

Cite This Study

Itami et al. (2025) studied this question.

synapsesocial.com/papers/68d466a831b076d99fa64fcehttps://doi.org/10.3390/cells14181459
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  5. 5Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex2010 · 43 citations