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This is a Quantitative Study study (also classified as: Experimental Study).

September 19, 2025

Synthesis and Antimicrobial Evaluation of Novel Oxopyrimido[1,2–a]pyrimidine Derivatives

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This research synthesizes new oxopyrimido derivatives and evaluates their antimicrobial activity against E. coli and B. subtilis.

Several synthesized derivatives demonstrated significant growth inhibition against Escherichia coli and Bacillus subtilis, indicating potential as antimicrobial agents.
The synthesis involved a Michael addition and cyclization to yield key oxopyrimido compounds with diverse structures.
The novel derivatives were confirmed using IR, ¹H NMR, ¹³C NMR, and mass spectrometry to ensure their structural integrity.
In vitro tests revealed notable antibacterial and antifungal activity against multiple strains, showcasing their therapeutic potential.

S. et al. (2025) studied this question.

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