Observational analysis reveals structural changes and increased chronic heart failure risk in men due to androgen deficiency, suggesting vital endocrine connections.
Recently, there has been an increase in cardiovascular diseases, especially among men, which is often associated with changes in the endocrine system, including age-related androgen deficiency. The key male sex hormone, testosterone, plays an important role in regulating metabolic and inflammatory processes, as well as in the contractility of the myocardium. However, the mechanisms linking testosterone deficiency to the development of cardiovascular diseases are still not fully understood, especially in the context of structural and functional changes in the heart. The aim of this study was to investigate the impact of androgen deficiency on the development of secondary cardiomyopathy in middle-aged men. The results showed that a decrease in testosterone levels in middle-aged patients leads to structural changes in the heart muscles and increases the risk of developing chronic heart failure.
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Смирнов et al. (2025) studied this question.
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