Structure–activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis, the main causative agent of eumycetoma.

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This is a In Vitro Study study (also classified as: Experimental Study).

Hung Phat Duong; Dmitrij Melechov; Wilson Lim; Ma Jingyi; Kymberley R. Scroggie; Rajendra Lingala; Benjamin I. Perry; Luiza R. Cruz; Rahman Shah Zaib Saleem; Peter J. Rutledge; Alice Motion; Wendy W. J. van de Sande; Matthew H. Todd

doi:10.1039/d5md00427f

January 1, 2025RSC Medicinal ChemistryOpen Access

Structure–activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis, the main causative agent of eumycetoma.

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Key Points

Fenarimol analogue EPL-BS1246 exhibits potent activity against Madurella mycetomatis, highlighting its potential.
In vitro assays demonstrated significant effectiveness, revealing a strong relationship between structure and activity.
Analysis of fenarimol analogues was performed through systematic evaluation of their effects on the fungal agent.
These findings support further development of fenarimol analogues targeting eumycetoma treatment.

Implication

Evaluation of fenarimol analogues reveals strong in vitro and in vivo efficacy against Madurella mycetomatis, indicating potential treatment avenues for eumycetoma.

Abstract

The fenarimol analogue EPL-BS1246 was previously discovered to be potent against Madurella mycetomatis, the causative agent of the neglected tropical disease eumycetoma. Further evaluation of a small set of fenarimol...

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Cite This Study

Duong et al. (2025) studied this question.

synapsesocial.com/papers/68d466b531b076d99fa65506 https://doi.org/10.1039/d5md00427f

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Structure–activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis, the main causative agent of eumycetoma.

Key Points

Implication

Abstract

Discussion

Cite This Study

Structure–activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis, the main causative agent of eumycetoma.

Key Points

Implication

Abstract

Discussion

Cite This Study

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