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Systematic review assesses efficacy and real-world effectiveness of asenapine for aggressive behaviour in psychiatric disorders, suggesting potential benefits.
Background Clinical decision-making for the pharmacological treatment of aggressive behaviour in psychiatry remains challenging. Asenapine, a second-generation antipsychotic with a higher affinity for dopamine D4 than for D2 receptors, may become a treatment option, although this remains to be demonstrated.
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Scala et al. (2025) studied this question.
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