Efficacy and Safety of Asenapine in Bipolar Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

March 9, 2026Psychopharmacology Bulletin

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Key Points

To assess the efficacy and safety of asenapine for treating bipolar disorder, particularly in acute mania.
Conducted a systematic review of randomized controlled trials
Included trials evaluating asenapine in patients with bipolar disorder
Analyzed data for efficacy and tolerability outcomes
Asenapine demonstrated significant efficacy in reducing symptoms of acute mania
Tolerability profile suggests manageable side effects
Review highlights favorable outcomes for short-term treatment with asenapine

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Systematic review finds asenapine effective for acute mania in bipolar disorder, suggesting positive treatment implications.

Asenapine is an effective short-term treatment for acute mania in bipolar disorder, with tolerability considerations.

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Muneer et al. (2026) studied this question.

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