Key result
Asenapine linked to reversible QTc prolongation and ventricular trigeminy in a bipolar patient.
Why the study?
Does asenapine cause QTc prolongation and ventricular trigemini in patients with bipolar disorder?
Case Report (n=1)
Does asenapine cause QTc prolongation and ventricular trigemini in patients with bipolar disorder?
Asenapine can cause significant QTc prolongation and ventricular trigemini, emphasizing the importance of cardiac monitoring when initiating or switching antipsychotics.
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May warrant QTc monitoring with asenapine in older adults; single case leaves arrhythmic risk open.
Gill et al. (2017) conducted a case report in Bipolar disorder (n=1). Asenapine was evaluated on QTc prolongation and ventricular trigemini. Treatment with asenapine in a 71-year-old female with bipolar disorder resulted in ventricular trigemini and a large increase in QTc interval, which ceased upon withdrawal of the drug.
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