Key result
Aripiprazole's potential to cause iatrogenic QTc prolongation in older adults was explored in a case report.
Why the study?
Does aripiprazole cause QTc prolongation in an elderly patient?
Case Report
Does aripiprazole cause QTc prolongation in an elderly patient?
This case report highlights the potential risk of QTc prolongation associated with aripiprazole use, particularly in the context of elderly patients.
Alerts clinicians to possible QTc risk with aripiprazole in older adults; leaves open confirmation via larger studies.
The use of neuroleptics in the elderly has been a topic of debate since 2005 when the US Food and Drug Administration issued a black-box warning of increased risk of mortality in elderly patients with dementia-related psychosis. Antipsychotic alternatives such as divalproex are sometimes favored on an "off-label" basis to manage agitation in the demented elderly, and antipsychotic use is often clinically necessary to treat psychosis in older adults, with or without dementia. Concurrently, risk for iatrogenic corrected QT (QTc) prolongation on electrocardiogram (ECG) remains a concern with the use of many antipsychotic agents because of its associated potential for fatal arrhythmias.
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Karz et al. (2015) conducted a case report in Psychosis in older adults. Aripiprazole was evaluated on QTc prolongation. Aripiprazole's potential to cause iatrogenic QTc prolongation in older adults was explored in a case report.
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