Key result
Coadministration of aripiprazole and haloperidol may lead to asymptomatic QTc prolongation, highlighting psychoactive polytherapy as a risk factor for prolonged cardiac repolarization.
Why the study?
Does coadministration of aripiprazole and haloperidol cause asymptomatic QTc prolongation?
Does coadministration of aripiprazole and haloperidol cause asymptomatic QTc prolongation?
Psychoactive polytherapy, such as the coadministration of aripiprazole and haloperidol, may increase the risk of QTc prolongation and subsequent arrhythmias.
May prompt QTc monitoring with aripiprazole-haloperidol coadministration; leaves open arrhythmia risk of psychoactive polytherapy.
Article Abstract Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text. Sir: Several non-antiarrhythmic drugs, including antipsychoticagents, have been shown to prolong cardiac repolarization,predisposing to torsades de pointes ventricular tachycardiaand sudden cardiac death.1 However, it is known that severalrisk factors may prolong QT interval, even in patients with anapparently normal baseline electrocardiogram (ECG).2 Psychoactivepolytherapy has to be included in these risk factorsdue to pharmacokinetic and pharmacodynamic interactions.3
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Leo et al. (2008) conducted a letter in QTc Prolongation. Coadministration of Aripiprazole and Haloperidol was evaluated on Asymptomatic QTc Prolongation. Coadministration of aripiprazole and haloperidol may lead to asymptomatic QTc prolongation, highlighting psychoactive polytherapy as a risk factor for prolonged cardiac repolarization.
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