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September 19, 2025Journal of Translational GastroenterologyOpen Access

The Gut–brain–immune Triad in Neurodegeneration: An Integrated Perspective

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Authors

SCSwarup K. ChakrabartiDCDhrubajyoti Chattopadhyay

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Overview

This review uncovers gut microbiota’s influence on neuroinflammation and immune modulation in neurodegenerative diseases.

Key Points

  • Neurodegenerative diseases show a distinct link between gut microbiota and immune response, influencing disease progression.
  • Altered gut microbiota leads to increased neuroinflammation and disrupts blood-brain barrier integrity in conditions like Alzheimer's and Parkinson's.
  • Animal models demonstrate how microbial metabolites affect synaptic function and neuronal degeneration in neurodegenerative diseases.
  • Research highlights significant gaps in understanding causality, necessitating more thorough, multifactorial studies in this domain.

Cite This Study

Chakrabarti et al. (2025) studied this question.

synapsesocial.com/papers/68d466b531b076d99fa65580https://doi.org/10.14218/jtg.2025.00027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Gut-Brain Axis in Neurodegeneration: Mechanistic Links Between Dysbiosis and Neuropathology.2026
  2. 2Investigating the Roles of Gut Microbiome in the Progression of Neurodegenerative Diseases: Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis (ALS)2024
  3. 3Gut Dysbiosis and Microbiota-Derived Metabolites in Neurodegenerative Diseases: Molecular and Biochemical Mechanisms Along the Gut–Brain Axis2026 · 15 citations
  4. 4From gut to brain: exploring the impact of microbiota, dysbiosis, and neuroinflammation in neurodegenerative disorders2025 · 11 citations
  5. 5The Microbiome–Neurodegeneration Interface: Mechanisms, Evidence, and Future Directions2026 · 6 citations