Case series reports positive effects of ripretinib on advanced gastrointestinal stromal tumors, suggesting improved accessibility could enhance patient outcomes.
The therapeutic armamentarium for advanced gastrointestinal stromal tumors (GISTs) is rapidly evolving and demands personalized strategies due to its increasing complexity. We are witnessing an expansion of the treatment modalities with new molecules being added to the same. Novel agents such as avapritinib and ripretinib have been granted Food and Drug Administration approval for platelet-derived growth factor α-D842V-mutant and refractory GIST patients, respectively. Ripretinib received its approval in May 2020 for individuals with advanced GIST who had been treated with three or more kinase inhibitors after publication of results of the INVICTUS trial. Here, we share our experience of four patients with previously treated advanced GIST who received ripretinib through an expanded access program. Our favorable experience with ripretinib warrants wider availability and easy accessibility of this drug in India for improving outcomes of patients with GIST.
No takes yet. Share an insight, caveat, or question.
Neelima et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: