CD9: Differential expression of normal bone marrow cellular components and leukemic myeloid blasts

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Research shows differential cd9 expression in normal myeloid progenitors and acute myeloid leukemia, suggesting diagnostic potential.

In acute myeloid leukemia, cd9 expression is typically higher compared to normal myeloid blasts and promyelocytes.
Flow cytometry revealed that committed myeloid progenitors had lower cd9 expression than hematopoietic stem cells.
Normal mature B cells serve as a reliable internal negative control for cd9 expression assessments.
Differential cd9 expression may help differentiate normal from abnormal myeloid progenitors, especially in PML::RARA AML.

Jasim et al. (2025) studied this question.

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