What question did this study set out to answer?

Identify clinically distinct molecular subgroups and develop a gene-expression-based outcome predictor for adult acute myeloid leukemia, particularly for intermediate-risk cases with normal karyotypes.

April 14, 2004New England Journal of MedicineOpen Access

Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

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Authors

LBLars BullingerNorthwestern University KDKonstanze DöhnerNorthwestern University EBEric BairLinköping University

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Implication

Molecular profiling study reveals novel prognostic subclasses in adult acute myeloid leukemia, indicating improved risk stratification beyond standard cytogenetics.

Key Points

Identify clinically distinct molecular subgroups and develop a gene-expression-based outcome predictor for adult acute myeloid leukemia, particularly for intermediate-risk cases with normal karyotypes.
Analyzed gene-expression levels using complementary-DNA microarrays in peripheral-blood or bone marrow samples from 116 adults with acute myeloid leukemia (45 with normal karyotypes).
Identified molecular subtypes via unsupervised hierarchical clustering and trained a supervised learning outcome predictor on 59 patients, validating it on an independent cohort of 57 patients.
Unsupervised clustering identified novel molecular subtypes of acute myeloid leukemia, uncovering two distinct prognostic subgroups in patients with normal karyotypes.
The 133-gene clinical-outcome predictor significantly predicted overall survival in the independent validation cohort (P=0.006) and within the normal-karyotype subgroup (P=0.046).
Multivariate analysis established the gene-expression predictor as an independent prognostic factor (odds ratio, 8.8; 95% confidence interval, 2.6 to 29.3; P<0.001).

Cite This Study

Bullinger et al. (2004) studied this question.

synapsesocial.com/papers/6a006842413f0c047f2d7692 https://doi.org/10.1056/nejmoa031046

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Implication

Molecular profiling study reveals novel prognostic subclasses in adult acute myeloid leukemia, indicating improved risk stratification beyond standard cytogenetics.

Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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