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September 20, 2025AntioxidantsOpen Access

The Dual Role of NOX4 in Cardiovascular Diseases: Driver of Oxidative Stress and Mediator of Adaptive Remodeling

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Authors

PLPauline LabbéMontreal Heart InstituteÉTÉric ThorinMontreal Heart InstituteNTNathalie Thorin‐TrescasesMontreal Heart Institute

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Overview

Observational analysis highlights nox4's dual role in oxidative stress and adaptive remodeling in cardiovascular diseases, suggesting its potential as a therapeutic target.

Key Points

  • NOX4's activity can be both protective and harmful in cardiovascular diseases, impacting heart function significantly.
  • Studies indicate that inhibiting or knocking out NOX4 can reduce fibrosis and inflammation in heart conditions like heart failure.
  • NOX4 acts as a redox sensor, helping maintain cellular balance and responding to oxidative stress and environmental changes.
  • The implications of targeting NOX4 in therapy are complex, as its effects depend on various factors, including stress type and duration.

Cite This Study

Labbé et al. (2025) studied this question.

synapsesocial.com/papers/68d469c131b076d99fa663c0https://doi.org/10.3390/antiox14091137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Loss of NOX2 (gp91<i>phox</i>) prevents oxidative stress and progression to advanced heart failure2014 · 57 citations
  2. 2NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies2011 · 182 citations
  3. 3Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System2012 · 763 citations
  4. 4NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFκB Signaling Pathways2015 · 247 citations
  5. 5Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders2026