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September 20, 2025Cancer Research

Abstract A067: Characterizing the ovarian cancer immune microenvironment in a syngeneic murine model

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Authors

AMAlexandra McMellenChildren's Hospital ColoradoMLMichael S. LeibowitzChildren's Hospital ColoradoBBBenjamin G. BitlerUniversity of Colorado Anschutz Medical Campus

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Implication

Observational analysis reveals variations in T cell infiltration across metastatic niches in ovarian cancer, suggesting targeted immunotherapy may enhance treatment efficacy.

Key Points

  • Greater T cell percentages are found in ascites compared to other tumor sites, indicating potential site-specific immune responses.
  • Using orthotopic syngeneic murine models, the study explores T cell characteristics within distinct ovarian cancer tumor niches.
  • Favorable T cell infiltration in omental tumors highlighted a higher prevalence of T-regulatory cells in PARPi-resistant cases, emphasizing therapeutic challenges.
  • Further examination of T cell functionality is essential, as current findings show inconsistent activation markers across different tumor environments.

Cite This Study

McMellen et al. (2025) studied this question.

synapsesocial.com/papers/68d469c131b076d99fa663d7https://doi.org/10.1158/1538-7445.ovarian25-a067
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A072: Altering the ovarian cancer tumor microenvironment using car t cell therapy2024
  2. 2Abstract B075: Spatial genomics identifies cancer cell cytokines regulating ovarian cancer immunity2024
  3. 3Abstract A078: In vivo tumor micro-environment characterization: preliminary results of an ovarian cancer patients-derived co-colture organoids platform2024
  4. 4Abstract A034: Spatial dynamics of vaccine-induced immunity in ovarian cancer: The central role of omental milky spots2025
  5. 5Abstract 2570: Reprogramming T-cell networks to overcome immune evasion in ovarian cancer relapse2026