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September 13, 2025British Journal of DermatologyOpen Access

Methodological Concerns in the EASE Study of Oleogel-S10 for Epidermolysis Bullosa: reply from authors

Dédée F. Murrell Christine Bodemer Anna L. Bruckner Tracy Cunningham Charles S. Davis María Emilia Fernández Dimitra Kiritsi Laura Maher Eli Sprecher Mauricio Torres Pradilla Johannes S. Kern

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Key Points

Authors clarify methodological concerns about the EASE Study, addressing critiques presented by Cao et al.
Concerns related to the trial's design and implementation were examined, leading to clarifications about oleogel-S10's efficacy.
The response emphasizes the importance of transparent methods in clinical trials for treatments like oleogel-S10.
These discussions underscore ongoing debates in the field regarding epidermolysis bullosa treatment methodologies.

Implication

Authors respond to criticism regarding methodological concerns in the EASE Study of oleogel-S10 for epidermolysis bullosa treatment.

Abstract

Authors response to ‘Methodological Concerns in the EASE Study of Oleogel-S10 for Epidermolysis Bullosa’ by Cao et al.

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Cite This Study

Murrell et al. (2025) studied this question.

synapsesocial.com/papers/68d469c131b076d99fa66423 https://doi.org/10.1093/bjd/ljaf365

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Methodological Concerns in the EASE Study of Oleogel-S10 for Epidermolysis Bullosa2025
2Efficacy and safety of Oleogel-S10 (birch triterpenes) for epidermolysis bullosa: results from the phase III randomized double-blind phase of the EASE studyRCT · 2022 · 78 citations
3Long‐Term Efficacy and Safety of Oleogel‐ <scp>S10</scp> (Birch Triterpenes) for Pediatric Patients With Epidermolysis BullosaRCT · 2026 · 1 citations
4Real‐World Experience With Oleogel‐S10 for Wounds in Epidermolysis Bullosa2025 · 3 citations
5Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa—Impact of Oleogel‐<scp>S10</scp>2025 · 5 citations