This method enables efficient direct C–H alkylation of allylic bonds, suggesting a new palladium pathway facilitated by light.
Direct C–H alkylation is one of the most important C–C bond formation events and is crucial to the efficient assembly of functionalized carbon skeletons in synthetic chemistry. We report herein a photoinduced palladium-catalyzed strategy for the direct alkylation of allylic C–H bonds. The success of this transformation relies on the use of 2-bromo-1,3-dimethylbenzene as a hydrogen atom transfer (HAT) mediator, in combination with a carbon nucleophile, facilitated by a palladium catalyst activated by blue light. Unlike classical Pd(II/0) pathways, this approach leverages the versatile reactivity of Pd(0/I/II) species through visible-light excitation, establishing a robust foundation for the feasibility of this synthetic methodology.
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Huang et al. (2025) studied this question.
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