This reaction demonstrates iron's role in creating (Z)-stereoselective α,β-unsaturated compounds using aldehydes, suggesting new methods for α-amino acids.
An iron‐catalyzed oxidative acylation of acylamido acrylates with abundant aldehydes has been developed. The use of mono N‐protected amino acids results in the unusual assembly of α,β ‐unsaturated compounds in a predictable (Z)‐stereoselective fashion, thereby offering a complementary tool toward the synthesis of unnatural γ ‐carbonyl α‐amino acid derivatives. Density functional theory studies provide insights into the stereodetermining step of the radical reaction pathway.
No takes yet. Share an insight, caveat, or question.
Kyriacou et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: