Phosphatidic Acid Reverses Obesity Induced by a High-Fat, High-Sugar Diet at the Transcriptional Level

Background: Obesity poses a significant threat to human health and is commonly caused by excessive dietary intake. Phosphatidic acid (PA) is one of the simplest diacylglycerol phospholipids, serving as a crucial precursor for the synthesis of triglycerides and other complex phospholipids. PA is also an important intermediate product in the process of fat digestion and absorption. Studies have shown that PA has muscle-building and fat-reducing effects, but it is currently unclear whether it can combat obesity induced by a high-fat, high-sugar diet (HFD). Methods: Using a model of obesity induced by a high-fat high-sugar diet, we found that the addition of PA to food could reverse HFD-induced obesity. Results: Addition of PA to food can reverse obesity induced by a high-fat diet. Transcriptomic analysis results indicate that this reversal also takes place at the molecular level. Further analysis suggests that PA may regulate fat metabolism by reversing the PPAR signaling pathway. Conclusions: Our study provides molecular evidence for the use of PA as an effective additive in weight-loss food products.