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This is a Case Report study (also classified as: Literature Review).

September 20, 2025Open Access

Unmasking lupus: Generalized lymphadenopathy mimicking lymphoma in Systemic Lupus Erythematosus: A case report and literature review

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Diagnostic confusion arose as generalized lymphadenopathy appeared to indicate non-hodgkin's lymphoma.
Correct diagnosis of systemic lupus erythematosus was established after observing nephrotic syndrome features.
Immunohistochemistry results and steroid response indicated an autoimmune rather than malignant cause.
This case emphasizes the need for differential diagnoses in patients showing signs of generalized lymphadenopathy.

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Case report illustrates the diagnostic overlap of lymphadenopathy with non-hodgkin's lymphoma and autoimmune conditions.

Githaiga et al. (2025) studied this question.

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