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September 20, 2025Journal of Cancer Research and Clinical OncologyOpen Access

Advancing our understanding of the influence of myeloid-derived suppressor cells in chronic myeloid leukemia

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Authors

XMXing MengYZYanlong ZhangHXHong Xu

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Overview

This review highlights the role of myeloid-derived suppressor cells in chronic myeloid leukemia, suggesting therapeutic implications and immune alterations.

Key Points

  • Myeloid-derived suppressor cells are important in the immune response and affect CML progression.
  • Chronic myeloid leukemia shows immune abnormalities due to the dysfunction of myeloid-derived suppressor cells.
  • Tyrosine kinase inhibitors effectively target leukemia but do not eliminate all cancer cells, leading to relapse.
  • Exploring the immune microenvironment can provide insights for new treatment strategies for chronic myeloid leukemia.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/68d469c831b076d99fa667c6https://doi.org/10.1007/s00432-025-06315-6
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  4. 4Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma2014 · 111 citations
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