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September 20, 2025Ophthalmology and TherapyOpen Access

Neovascular Age-Related Macular Degeneration Treated with Aflibercept: Five-Year Follow-Up and Correlation with Optical Coherence Tomography Biomarkers in a Real-World Setting

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Authors

MBMassimiliano BorselliMagna Graecia UniversityMEMutasem ElfalahUniversity of JordanTTTeresa Angela TrunfioUniversità Campus Bio-Medico

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Overview

Retrospective analysis shows aflibercept improves visual acuity in neovascular age-related macular degeneration, suggesting correlations with OCT biomarkers.

Key Points

  • Visual acuity improved after loading but declined by year 5—performing better in those with high initial visual acuity.
  • Significant decreases in central foveal thickness observed in both types of neovascular age-related macular degeneration after treatment.
  • OCT biomarkers, including subretinal fluid and hyperreflective spots, provide insights into treatment outcomes and visual prognosis.
  • Type 1 macular neovascularization often shows reduced biomarkers, while type 2 may develop more complications over time.

Cite This Study

Borselli et al. (2025) studied this question.

synapsesocial.com/papers/68d469ce31b076d99fa66c7dhttps://doi.org/10.1007/s40123-025-01232-w
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