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September 20, 2025Annals of HematologyOpen Access

Genetic analysis of thalassemia in putian: comparative insights into mutation spectra with other global regions

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Authors

LYLiumin YuPutian UniversityGXGuanghui XuAnhui UniversityZCZhanfei ChenPutian University

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Implication

Comparative insights reveal unique thalassemia mutation spectra in Putian, highlighting significant epidemiological findings.

Key Points

  • Thalassemia mutations were identified in 35.49% of individuals tested, indicating a high prevalence in Putian.
  • The study found a predominant presence of α-thalassemia deletions and β-thalassemia genotypes among confirmed cases.
  • Population migration contributes new thalassemia genotypes, influencing the mutation landscape in the region.
  • Carriers of thalassemia genes in the infertile population were found to be twice as frequent compared to the local general population.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68d46aa631b076d99fa673a9https://doi.org/10.1007/s00277-025-06604-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Third-generation sequencing identified a novel complex variant in a patient with rare alpha-thalassemia2024 · 6 citations
  2. 2Thalassemia in India2022 · 8 citations
  3. 3The Molecular Spectrum of β- and α-Thalassemia Mutations in Non-Endemic Umbria, Central Italy2016 · 14 citations
  4. 4Analysis of Common Beta-Thalassemia (β-Thalassemia) Mutations in East Java, Indonesia2022 · 15 citations
  5. 5Alpha-Thalassaemia in Association with Beta-Thalassaemia Patients in Malaysia: A Study on the Co-Inheritance of Both Disorders2008 · 21 citations