Direct palladium-catalyzed C-H arylation of bioactive triazolyl-C-nucleosides on a key position of the heterocyclic base

Q: What type of study is this?

This is a Experimental Study study.

Bartosz Godlewski; Nina Božinović; Quentin Joachim; Olivier Monasson; Nadège Lubin-Germain; Angélique Ferry

doi:10.1039/d5cc04215a

January 1, 2025Chemical Communications

Direct palladium-catalyzed C-H arylation of bioactive triazolyl-C-nucleosides on a key position of the heterocyclic base

View Full Paper

Ask AI

Bookmark

Share

Key Points

Direct palladium-catalyzed C-H arylation enhances bioactive nucleosides, expanding their therapeutic potential.
The study highlights the utility of triazolyl-C-nucleosides in developing antiviral and anticancer therapeutics.
A novel approach for modifying nucleosides could significantly impact drug development in oncology and virology.
The findings point to the importance of exploring new chemical spaces in nucleoside chemistry for future applications.

Implication

This research demonstrates direct C-H arylation in nucleosides, suggesting new therapeutic potentials in antiviral and anticancer drugs.

Abstract

Regarding the potential of nucleosides in therapeutics especially as antiviral and anticancer drugs, the expansion of the chemical space of such molecules appears urgent. Herein, a direct palladium-catalyzed C-H arylation...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Godlewski et al. (2025) studied this question.

synapsesocial.com/papers/68d46aa631b076d99fa673c9 https://doi.org/10.1039/d5cc04215a

View Full Paper

Ask AI

Bookmark

Share

Direct palladium-catalyzed C-H arylation of bioactive triazolyl-C-nucleosides on a key position of the heterocyclic base

Key Points

Implication

Abstract

Discussion

Cite This Study

Direct palladium-catalyzed C-H arylation of bioactive triazolyl-C-nucleosides on a key position of the heterocyclic base

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading