This method demonstrates efficient C(sp3)−H acylation using a photo-induced strategy, avoiding metals and harsh conditions.
Heterobenzylic C(sp3)−H functionalization of isoindolinones remains challenging yet highly desirable. Herein, we present a photo-induced hydrogen atom transfer (HAT) strategy for heterobenzylic C(sp3)−H acylation of isoindolinones using acyl azolium salts under mild reaction conditions. This metal-free protocol offers excellent functional group compatibility and avoids the usage of Lewis acids or oxidants, providing a sustainable and efficient approach to C–H acylation.
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Muthuvel et al. (2025) studied this question.
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