This work demonstrates a metal-free strategy for indole C2 functionalization in aqueous media, indicating a promising approach for organic synthesis.
In this work, we report a metal-free strategy for indole C2 functionalization in aqueous media, enabled by ion-pair catalysis via transient N-Acyliminium intermediates. This approach overcame the intrinsic instability of...
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Liu et al. (2026) studied this question.
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