Lewis‐Acid Mediated Hierarchical Ce/P‐WO₃ Microbeggarticks‐Nanoneedles for High‐Efficiency Listeria Monocytogenes Detection

Listeria monocytogenes , a common foodborne pathogen, poses significant risks to public health. The 3‐hydroxy‐2‐butanone (3H‐2B) produced during its metabolism serves as a biomarker for indirectly assessing microbial contamination in foods. Existing semiconductor gas sensors for 3H‐2B often struggle to balance high stability and sensitivity due to the trade‐off between the number of active sites and the stability of the sensing materials. This study synthesized polyoxomethoxide‐derived Ce modified P‐WO 3 hierarchical microbeggarticks nanoneedles by using a novel cluster‐nuclei assembly strategy, where Ce doping synergistically amplifies Lewis acidity is enabled by W‐O v ‐Ce ternary active sites, which stabilize the W 5+ /W 6+ mixed valence states, enhancing 3H‐2B chemisorption and material durability. The 3H‐2B micro‐electromechanical system (MEMS) sensor exhibits both reliable repeatability and exceptional long‐term stability over 30 weeks. The underlying mechanism is elucidated using in situ Fourier transform infrared spectroscopy and on‐line mass spectrometry. Furthermore, the sensor exhibited high selectivity and sensitivity for detecting Listeria monocytogenes . Density functional theory calculations indicated that Ce 4+ embedded in the P‐WO 3 lattice resulted in higher adsorption energy for 3H‐2B. Furthermore, the device integrates a wireless sensor module enabling remote, real‐time detection of L. monocytogenes , providing an effective solution for global quality assessment of salmon during cold chain transportation.